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AssigneeGlaxo Group Limited
InventorsWilliam J. Dower, Ronald W. Barrett, Steven E. Cwirla, Christian M. Gates, Peter J. Schatz, Palaniappan Balasubramanian, Christopher R. Wagstrom, Richard Wayne Hendren, Randolph B. Deprince, Surekha Podduturi, Qun Yin
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Described are peptides and peptide mimetics that bind to and activate the thrombopoietin receptor. Such peptides and peptide mimetics are useful in methods for treating hematological disorders and particularly, thrombocytopenia resulting from chemotherapy, radiation therapy, or bone marrow transfusions as well as in diagnostic methods employing labeled peptides and peptide mimetics.
A method of activating a thrombopoietin receptor in a cell, comprising contacting said cell with an effective amount of a compound covalently attached to a hydrophilic polymer, said compound selected from the group consisting of:
A method of treating a patient suffering from thrombocytopenia, comprising administering to said patient a therapeutically effective dose of a compound covalently attached to a hydrophilic polymer, said compound selected from the group consisting of:
A method according to claim 26 wherein said thrombocytopenia is due to bone marrow transfusion.
A method of prophylactically treating a patient at risk of thrombocytopenia, comprising administering to said patient a prophylactically effective amount of a compound covalently attached to a hydrophilic polymer, said compound selected from:
Dependencies are inferred from the claim text.