US 6,251,655 B1 · Process for increasing the production of penicillin G (benzylpenicillin) in Penicillium chrysogenum by expression of the PCL gene

Process for increasing the production of penicillin G (benzylpenicillin) in Penicillium chrysogenum by expression of the PCL gene

AssigneeAntibioticos S.p.A.

InventorsBaltasar Minambres Rodriguez, Honorina Martinez Blanco, Elias Rodriguez Olivera, Belen Garcia Alonso, Jose Manuel Fernandez Canon, Jose Luis Barredo Fuente, Bruno Diez Garcia, Carmen Schleissner Sanchez, Miguel Angel Moreno Valle, Francisco Salto Maldonado, Jose Maria Luengo Rodriguez

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Abstract

An isolated DNA encoding phenyl acetyl-CoA-ligase and a process of increasing the production of penicillin G in a strain of Penicillium chrysogenum by transforming the strain with the isolated DNA. Also vectors and host organisms having the isolated DNA.

Claims12

Dependent claims

An isolated DNA sequence comprising SEQ ID NO:

1, or a sequence hybridizing to the complement of SEQ ID NO:
1 under stringent conditions and encoding a phenylacetyl-CoA ligase.

Dependencies are inferred from the claim text.