Immuno-reactive peptide CTL epitopes of human cytomegalovirus
OwnerDon Jeffrey Diamond, Joanne Yorkinventors
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Abstract
The invention provides a plurality of peptides (and immunologically functional variants thereof) which are immunogenic epitopes recognized by CD8+ class I MHC restricted cytotoxic T-lymphocytes of patients harboring latent cytomegalovirus (HCMV) infection. The peptides are capable of activating CTLs and CTLp's in the absence of active viral replication, and thus are useful for eliciting a cellular immune response against HCMV by normal and immunodeficient subjects. Polypeptide and lipopeptide vaccines, with and without adjuvants, also are disclosed.
Claims9
A peptide according to SEQ ID NO:
- 19.
A peptide according to SEQ ID NO:
- 20.
A vaccine against human cytomegalovirus comprising a peptide selected from SEQ ID NO:
- 1, SEQ ID NO:
- 19 and SEQ ID NO:
- 20.
Dependencies are inferred from the claim text.