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US 6,248,574 B1Granted
Polypeptides selectively reactive with antibodies against human immunodeficiency virus and vaccines comprising the polypeptides
OwnerAvigdor Shaffermanninventor
Life of this patent
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Abstract
Highly conserved polypeptide sequences derived from gp41 and gp120, preferably from eleven to twenty-one amino acids in length, are joined (for example, via DNA recombinant techniques) to a non-HIV protein or polypeptide sequence comprising an amino-acid sequence not naturally encoded by the HIV genome, thereby forming a fusion protein. Such fusion proteins possess attributes that make them suitable for use in the diagnosis, treatment and prevention of HIV infection.
Claims13
A fusion protein comprising:
- an amino acid sequence selected from the group consisting of NVTENFNMWKN, KAKRRVVQREKRAVG, and EESQNQQEKNEQELLELDKWA;
- and
- a non-HIV polypeptide sequence, wherein said amino-acid sequence and said polypeptide sequence comprise the backbone of said fusion protein, wherein said fusion protein reacts with an HIV-positive serum.
Dependencies are inferred from the claim text.