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US 6,248,229 B1Granted
Detection of analytes using reorganization energy
AssigneeClinical Micro Sensors, Inc.
InventorThomas J. Meade
Life of this patent
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Abstract
The invention relates to novel methods and compositions for the detection of analytes using the nuclear reorganization energy, λ, of an electron transfer process.
Claims21
A composition for use in a competition assay comprising an electrode comprising:
- a) a covalently attached binding ligand, wherein said binding ligand is selected from the group consisting of a target analyte and a target analyte analog;
- and
- b) a covalently attached solvent accessible transition metal complex comprising a metal selected from the group consisting of manganese, technetium, rhenium, iron, ruthenium, osmium, cobalt, rhodium, iridium, nickel, palladium, platinum, copper, silver and gold;
- such that upon binding of a binding partner of said target analyte or said analog, a solvent inhibited transition metal complex is formed.
1 more element
An apparatus for use in a competition assay for the detection of target analytes comprising:
- a) a test chamber comprising a first measuring electrode and at least a second electrode, wherein said first measuring electrode comprises:
- i) a covalently attached binding ligand, wherein said binding ligand is selected from the group consisting of a target analyte and a target analyte analog;
- ii) a covalently attached solvent accessible transition metal complex comprising a metal selected from the group consisting of manganese, technetium, rhenium, iron, ruthenium, osmium, cobalt, rhodium, iridium, nickel, palladium, platinum, copper, silver and gold;
- such that upon binding of a binding partner of said target analyte or said analog, a solvent inhibited transition metal complex is formed;
- and
- b) an AC/DC voltage source electrically connected to said test chamber.
3 more elements
Dependencies are inferred from the claim text.