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US 6,248,127 B1Granted
Thromboresistant coated medical device
AssigneeMedtronic AVE, Inc.
InventorsChirag B. Shah, Laurel L Wolfgang
Life of this patent
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Abstract
Coatings are provided in which biopolymers may be covalently linked to a substrate. Such biopolymers include those that impart thromboresistance and/or biocompatibility to the substrate, which may be a medical device. Coatings disclosed herein include those that permit coating of a medical device in a single layer, including coatings that permit applying the single layer without a primer. Suitable biopolymers include heparin complexes, and linkage may be provided by a silane having isocyanate functionality.
Claims13
A medical device having a coating comprising the product of the reaction of:
- a silane having at least one functional group selected from the group consisting of an isocyanate, an isothiocvanate, an ester, an anhydride, an acyl halide, an alkyl halide, an epoxide and an aziridine;
- and
- a biopolymer.
Dependencies are inferred from the claim text.