Technique for using heat flow management to treat brain disorders
AssigneeThe Johns Hopkins University
InventorsRonald P. Lesser, W. Robert S. Webber
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AssigneeThe Johns Hopkins University
InventorsRonald P. Lesser, W. Robert S. Webber
Estimating the term…
A method of treating a brain disorder by heat transfer from brain tissue comprising the steps of surgically cutting a heat transfer aperture into a patient's skull, thereby exposing a predetermined portion of patient's brain; surgically implanting into said heat transfer aperture a heat pump having one or more electrical sensor elements and one or more temperature sensor elements; surgically implanting a heat transfer management unit in a body cavity of said patient such that a micro controller of the heat transfer management unit is connected to one or more activity sensor elements and one or more temperature sensor elements contacting brain tissue and connecting the heat transfer management unit to said heat pump via a lead bundle. Optionally, the heat transfer unit may be located external to the patient's body. Responsive to signals from one or more activity or temperature sensor elements, mathematical algorithms of the heat transfer management unit determine abnormal brain activity, causing the heat pump to remove heat from the brain tissue into a heat sink, thereby cooling the predetermined portion of the patient's brain. This technique utilizes acute hypothermia by means of a Peltier cooler or similar device to cool the brain temperature to reduce or prevent seizure initiation and/or propagation. The method may be used in association with brain stimulation and/or drug application to acutely avoid the occurrence of a seizure episode.
A method of treating a brain disorder by heat transfer from brain tissue comprising the steps of:
A method of controllably warming a hypothermic brain by heat transfer to brain tissue comprising the steps of:
A method for control of central nervous system tissue swelling or inflammation by controlled cooling comprising the steps of:
A method of controlling swelling, inflammation or localized pain in a non-central nervous system organ by regionally or locally directed cooling to said organ comprising the steps of:
Dependencies are inferred from the claim text.