Sensors
AssigneeNovartis AG
InventorsAdrian Waldner, René Beerli, Steven Mark Barnard
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Abstract
Sensors for the qualitative and quantitative determination of K+ ions in aqueous systems are described, which consist essentially of a carrier and an active layer applied to this carrier, whereby the active layer contains a polymer in which is dispersed at least one modified valinomycin, in which a radical of a fluorescence dye which emits in long waves, preferably an acridine or fluorescein, with an emission wave length of >550, is covalently bound.
Claims22
A sensor for the qualitative and quantitative determination of K+ ions in aqueous systems, which consist essentially of a carrier and an active layer applied to the carrier, wherein the active layer contains a polymer in which at least one modified valinomycin of formula I is dispersed,
- in which one of radicals R1 to R12 signifies a group of formula a,
- in which Ra signifies hydrogen or methyl, m and n, independently of one another, denote 0 to 6, whereby in the alkylene group —(CnH2n)— for n>0, a methylene group can be replaced by a phenylene or cycloalkylene radical, L is a bridging member formed by the reaction of two functional groups which are capable of reacting together, and A signifies the radical of a fluorescence dye emitting in long waves with an emission wave length of >550 nm, or one of radicals R1 to R12 signifies a group of the formula:
- and the remaining radicals R1 to R12, independently of one another, signify methyl or isopropyl;
- wherein an intensity of fluorescence of the sensor increases with increasing K+ ion concentration.
A coating composition comprising a polymer and a compound of formula I
- in which one of the radicals R1 to R12 is a group of formula a,
- —CHRa—(CnH2n)—L—(CmH2m)—A (a),
- wherein
- Ra is hydrogen or methyl;
- each of m and n, independently of one another, is 0 to 6;
- in the alkylene group —(CnH2n)— for n>0, a methylene group can be replaced by a phenylene or cycloalkylene radical;
- L is a bridging member formed by the reaction of two functional groups which are capable of reacting together;
- A is a radical of a fluorescence dye emitting in long waves with an emission wave length of >550 nm;
- or one of the radicals R1 to R12 is a group of the formula:
- and each of the remaining radicals R1 to R12, independently of one another, is methyl or isopropyl;
- wherein, in the presence of K+ ions in aqueous systems, an intensity of fluorescence of the coating composition increases with increasing K+ ion concentration.
A compound of formula I
- in which one of the radicals R1 to R12 is a group of formula a,
- —CHRa—(CnH2n)—L—(CmH2m)—A (a),
- wherein
- Ra is hydrogen or methyl;
- each of m and n, independently of one another, is 0 to 6;
- in the alkylene group —(CnH2n)— for n>0, a methylene group can be replaced by a phenylene or cycloalkylene radical;
- L is a bridging member formed by the reaction of two functional groups which are capable of reacting together;
- A is a radical of a fluorescence dye emitting in long waves with an emission wave length of >550 nm;
- or one of the radicals R1 to R12 is a group of the formula:
- and each of the remaining radicals R1 to R12, independently of one another, is methyl or isopropyl, with the proviso that where one of the radicals R3, R7, or R11 is a group —(CnH2n)—L—(CmH2m)—A and the remainder of radicals R1 to R12 are the same as in natural valinomycin, A is not the 5-dimethylamino-1-naphthyl radical if n is 3 and m is 0 and the alkylene group —(C3H6)— is a trimethylene group and the binding element L is —NH—SO2—;
- wherein, in the presence of K+ ions in aqueous systems, an intensity of fluorescence of the compound increases with increasing K+ ion concentration.
Dependencies are inferred from the claim text.