Human asparaginyl-tRNA synthetase DNA
AssigneeBoard of Trustees operating Michigan State University
InventorsMichael A. Kron, Michael M. Hartlein, Michito Hirikata
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Abstract
The CDNA sequence of human cytosolic asparaginyl-tRNA synthesis AsnRS, the bacterial expression of the recombinant enzyme and its activity assays with different sources of tRNA is described. The reactivity with a human autoimmune serum is described. The implication of the human cytoplasmic AsnRS in an autoimmune disorder is a property of this enzyme.
Claims12
An isolated nucleic acid sequence which encodes a human asparaginyl-tRNA synthetase having the amino acid sequence in SEQ ID NO:2.
An isolated nucleic acid sequence which encodes a fusion protein comprising a human asparaginyl-tRNA synthetase, which human asparaginyl-tRNA synthetase has the amino acid sequence in SEQ ID NO:2.
The recombinant host cell that is Escherichia coli strain BL21 (DE3) deposited under ATCC Accession No. PTA-2657.
Dependencies are inferred from the claim text.