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US 6,242,637 B1Granted
Substituted heterocylic compounds, method of preparing them and pharmaceutical compositions in which they are present
AssigneeSanofi-Synthelabo
InventorsXavier Emonds-Alt, Isabelle Grossriether, Patrick Gueule, Vincenzo Proietto, Didier Van Broeck
Life of this patent
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Abstract
The invention relates to compounds of the formula in which: A is a divalent radical selected from: A1) —O—CO— A2) —CH2—O—CO— A3) —O—CH2—CO— A4) —O—CH2—CH2— A5) —N(R1)—CO— A6) —N(R1)—CO—CO— A7) —N(R1)—CH2—CH2— A8) —O—CH2— in which: R1 is a hydrogen or a (C1-C4)-alkyl; and Am is a nitrogen-containing heterocycle.
Claims2
A compound of the formula
- in which:
- m is 2 or 3;
- Ar1 is a phenyl group which is unsubstituted or monosubstituted or polysubstituted by a substituent which is a halogen atom, a hydroxyl group, a (C1-C4)-alkoxy group, a (C1-C4)-alkyl group, a trifluoromethyl group or a methylenedioxy group, said substituents being identical or different;
- a thienyl group which is unsubstituted or substituted by a halogen atom;
- a benzothienyl group which is unsubstituted or substituted by a halogen atom;
- a naphthyl group which is unsubstituted or substituted by a halogen atom;
- an indolyl group which is unsubstituted or N-substituted by a (C1-C4)-alkyl group or a benzyl group;
- an imidazolyl group which is unsubstituted or substituted by a halogen atom;
- a pyridyl group which is unsubstituted or substituted by a halogen atom;
- or a biphenyl group;
- and
- E is a hydrogen or an O-protecting group;
- L is an aminomethyl group;
- D is a group —O—G;
- wherein
- G is a hydrogen or an O-protecting group.
13 more elements
Dependencies are inferred from the claim text.