Adamantane derivatives

A compound of general formula

• wherein A represents a CH2 group;
• B represents a hydrogen or halogen atom;
• D represents a group CH2, OCH2, NHCH2 or CH2CH2;
• R represents a phenyl group, which may be optionally substituted by one or more substituents independently selected from a halogen atom or a cyano, carboxyl, hydroxyl, nitro, halo-C1-C6-alkyl, —N(R1)—C(═O)—R2, —C(O)NR3R4, —NR5R6, C3-C8-cycloalkyl, 3- to 8-membered heterocyclyl, C3-C8-cycloalkyloxy, C1-C6-alkylcarbonyl, phenoxy, benzyl, C1-C6-alkylthio, phenylthio, C1-C6-alkoxycarbonyl, C1-C6-alkylsulphinyl or C1-C6-alkylsulphonyl group, or a C1-C6-alkyl or C1-C6-alkoxy group optionally substituted by one or more substituents independently selected from a halogen atom or an amino, carboxyl, hydroxyl, C1-C6-alkoxy, (di)C1-C6-alkylamino, C1-C6-alkoxycarbonyl, imidazolyl, morpholinyl, piperldinyl or pyrrolidinyl group;
• R1 represents a hydrogen atom or a C1-C6-alkyl or C3-C8-cycloalkyl group;
• R2 represents a C1-C6-alkyl or C3-C8-cycloalkyl group;
• and
• R3, R4, R5 and R6 each independently represent a hydrogen atom or a C1-C6-alkyl or C3-C8-cycloalkyl group;
• with the provisos that (i) when A is CH2, B is H and D is CH2, then R does not represent a phenyl, ortho-carboxyphenyl, ortho-nitrophenyl, ortho-aminophenyl, ortho-(dimethylaminoethyl)phenyl, methylphenyl or para-phenoxyphenyl group, and (ii) when A is CH2, B is Br and D is CH2, then R does not represent an orthocarboxyphenyl group, and (iii) when A is CH2, B is H and D is CH2CH2, then R does not represent a phenyl group, and (iv) when A is CH2 D is CH2 or CH2CH2 and R represents a substituted phenyl group, the substituent or substituents present do not comprise, in an ortho position, a C1-C6-alkoxy group substituted by an amino, (di)C1-C6-alkylamino, imidazolyl, morpholinyl, piperidinyl or pyrrolidinyl group;
• or a pharmaceutically acceptable salt or solvate thereof.