Method of promoting erythropoiesis
AssigneeUniversity of Southern California
InventorsKathleen E. Rodgers, Gere DiZerega
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Abstract
The present invention provides methods, compounds, pharmaceutical compositions, and kits for the augmentation of erythropoiesis by potentiating erythropoietin-induced differentiation with angiotensinogen, angiotensin I (AI), AI analogues, AI fragments and analogues thereof, angiotensin II analogues, AII fragments or analogues thereof or AII AT2 type 2 receptor agonists as a therapeutic adjunct. The method is useful for the treatment of congenital or acquired aplastic or hypoplastic anemia associated with chronic renal failure, end-stage renal disease, renal transplantation, cancer, AIDS, chemotherapy, radiotherapy, bone marrow transplantation and chronic diseases.
Claims11
A method for augmenting erythropoiesis comprising contracting erythroid progenitor cells with an amount of at least one active agent effective to augment erythropoiesis wherein the agent consists of a peptide comprising the amino acid sequence of SEQ ID NO:4 for a time and under conditions effective to augment erythropoiesis.
Dependencies are inferred from the claim text.