Process for producing malonic acid derivatives
AssigneeMitsubishi Rayon Co., Ltd.
InventorsEiji Ozaki, Kanehiko Enomoto, Takakazu Endo
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Abstract
The present invention relates to a method for preparing a malonic acid monoester represented by Formula (II): HOOCCH2COOR (II) wherein R is alkenyl, aryl, aralkyl or C1-20 alkyl, comprising treating a cyanoacetic acid ester represented by Formula (I): NCCH2COOR (I) wherein R is defined in Formula (II), with a culture, cells or a product from treated cells of a microorganism belonging to the genus Corynebacterium, Gordona or Rhodococcus and having nitrilase activity to thereby hydrolyze the cyanoacetic acid ester.
Claims11
A method for preparing a malonic acid monoester represented by formula (II):
- HOOC—CH2—COOR (II)
- wherein R is alkenyl, aryl, non-substituted aralkyl or C1-20 alkyl, comprising treating a cyanoacetic acid ester represented by formula (I):
- NC—CH2—COOR (I)
- wherein R is as defined above,
- with a culture, cells or a product from treated cells of a microorganism belonging to the genus Corynebacterium, Gordona or Rhodococcus and having nitrilase activity, to hydrolyze said cyanoacetic acid ester.
A method for preparing a malonic acid monoester represented by formula (II′):
- HOOC—CH2—COOR′ (II′)
- wherein R′ is alkenyl, aryl, non-substituted aralkyl or C3-20 alkyl,
- comprising treating a cyanoacetic acid ester represented by formula (I′):
- NC—CH2—COOR′ (I′)
- wherein R′ is as defined above,
- with a culture, cells or a product from treated cells of a microorganism having nitrilase activity, to hydrolyze said cyanoacetic acid ester.
Dependencies are inferred from the claim text.