D-mannitol and its preparation
AssigneesTakeda Chemical Industries, Ltd., Bayer Aktiengesellschaft
InventorsTomohiro Yoshinari, Fritz Schueckler, Norbert Poellinger, Shinji Maegata
Life of this patent
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Abstract
D-mannitol having a specific surface area of not less than about 1 m2/g is disclosed. The D-mannitol shows improved compressibility and is useful as an excipient.
Claims3
A process for preparing a D-mannitol said process comprising moistening the surface of δ form D-mannitol crystals with a water-soluble solvent without dissolving the δ form D-mannitol crystals completely in the water-soluble solvent, followed by drying the moistened δ form D-mannitol crystals to obtain the D-mannitol, said water-soluble solvent being in an amount of about 3 to about 70 W/W % based on the weight of the δ form D-mannitol crystals, said D-mannitol (a) being in the 5 form crvstals alone or a mixture of the β form crystals with the δ form crystals and (b) having a specific surface area of not less than about 1 m2/g.
A D-mannitol, which is the P form crystals alone or a mixture of the β form crystals with the δ form crystals, said D-mannitol having a specific surface area of not less than about 1 m2/g and being produced by a process which comprises moistening the surface of δ form D-mannitol crystals with a water-soluble solvent without dissolving the δ form D-mannitol crystals completely in the water-soluble solvent, followed by drying the moistened δ form D-mannitol crystals to obtain the D-mannitol.
A process for preparing a D-mannitol, said process comprising moistening the surface of δ form D-mannitol crystals with a water-soluble solvent without dissolving the δ form D-mannitol crystals completely in the water-soluble solvent, followed by drying the moistened δ form D-mannitol crystals to obtain the D-mannitol, said D-mannitol (a) being in the β form crystals alone or a mixture of the P form crystals with the δ form crystals and (b) having a specific surface area of not less than about 1 m2/g.
Dependencies are inferred from the claim text.