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AssigneeSontra Medical, Inc.
InventorsStephen Rowe, Joseph Kost, Samir S. Mitragotri, Michael Pishko, Matthew Davis
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Methods and devices for application of ultrasound to a small area of skin for enhancing transdermal transport. An ultrasound beam having a first focal diameter is channelled into a beam having a second, smaller diameter without substantial loss of energy. Higher energy ultrasound can be used while causing less pain. Alternatively, ultrasound energy is applied through a vibrating element positioned just contacting, above or extending into the skin. Use of the element facilitates extraction of analyte and may enhance drug delivery. A two step noninvasive method involves application of ultrasound to increase skin permeability and removal of ultrasound followed by transdermal transport that can be further enhanced using a physical enhancer.
A device for application of ultrasound to the skin for enhancing transdermal transport, the device comprising an ultrasound transducer capable of emitting ultrasound at a frequency between 20 kHz and 2 MHz and walls forming a chamber for containing coupling medium,
A method of enhancing transdermal transport, comprising the steps:
Dependencies are inferred from the claim text.