Biopolymer array inspection
AssigneeAgilent Technologies, Inc.
InventorWilliam D. Fisher
Life of this patent
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Abstract
A method of fabricating a biopolymer array, and an apparatus which can execute the method. droplets of fluid carrying the biopolymer or a biomonomer are deposited onto a front side of a transparent substrate. Light is directed through the substrate from the front side, back through a substrate back side and a first set of deposited droplets on the first side to an image sensor. The substrate may be mounted by means of a chuck with parallel channels, and a scanning operation of a droplet dispensing head, light source, and sensor conducted in unison in the direction of the channels.
Claims38
A method comprising:
- (a) depositing droplets of fluid carrying a biopolymer or a biomonomer onto a front side of a transparent substrate so as to fabricate a biopolymer array;
- and
- (b) directing light through the substrate from the front side then backward through the substrate and a first set of deposited droplets on the substrate front side, to an image sensor.
An apparatus for fabricating a biopolymer array, comprising:
- (a) a mount on which a transparent substrate can be mounted;
- (b) a deposition head to deposit droplets of a fluid carrying the biopolymer or a biomonomer onto a front side of the mounted substrate;
- (c) a light source to direct light through the mounted substrate from the front side;
- (d) a reflector to reflect light from the source which has passed through the mounted substrate backward through the mounted substrate and a first set of deposited droplets on the front side;
- and
- (e) an image sensor facing a front side of the mounted substrate to receive the reflected light after it has passed back through the first droplet set.
Dependencies are inferred from the claim text.