Stabilizers for live vaccines
AssigneePasteur Merieux Serums & Vaccins
InventorsBernard Fanget, Alain Francon
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Abstract
Stabilizers for live vaccines and attenuated mono- or multivalent live vaccines, stabilized vaccines containig such stabilizers, and methods for preparing such vaccines, are disclosed. Said stabilizers for vaccines containing one or more attenuated live viruses include one or more components selected from each of the following groups: amino acids, disaccharides, polyalcohols and buffer solutions, with the proviso that one component selected from the disaccharide group is saccharose.
Claims37
A stabilizing agent for live attenuated viral vaccines which is free of protein of animal origin comprising:
- dextran, one or more components selected from the group consisting of urea and urea derivatives, and one or more components selected from each of the following groups:
- amino acids, disaccharides, polyalcohols, and buffer solutions with the proviso that one component selected from the disaccharide group is sucrose.
A stabilizing agent for live attenuated viral vaccines which is free of protein of animal origin comprising dextran, and at least one component from each of the following groups:
- (a) urea and urea derivatives,
- (b) amino acids,
- (c) disaccharides and
- (d) polyalcohols,
- wherein the components are in a buffer solution with the proviso that one component selected from the disaccharide group is sucrose.
Dependencies are inferred from the claim text.