Stents with hybrid coating for medical devices

A stent comprising:

• a substantially tubular body;
• means for inhibiting restenosis;
• means for adhering said restenosis inhibiting means to said stent body and releasing said restenosis inhibiting means from said stent body over time;
• and
• means for rendering said stent body non-thrombogenic.

A stent comprising:

• a substantially tubular body;
• a polymer having organic acid functional groups;
• a first coating layer including a first therapeutic agent admixed with said polymer and a polyfunctional crosslinking agent covalently bonded to said polymer organic acid functional groups;
• and
• a second coating layer disposed over said first coating layer including a second therapeutic agent covalently bonded to said polyfunctional crosslinking agent.

A method for providing a substrate with a biocompatible and restenosis inhibiting coating comprising the steps of:

• coating said substrate with a first aqueous coating composition including a polymer having organic acid functional groups, a first therapeutic agent, an excess of a polyfunctional crosslinking agent having functional groups capable of reacting with organic acid groups;
• drying said first coating composition to obtain a substantially water insoluble coating layer still including functional groups being reactive with organic acid groups;
• forming a non-thrombogenic surface over said first coating composition by contacting said dried first coating composition with a second aqueous coating composition including heparin;
• and
• drying said second coating, to bond said heparin to said excess crosslinking agent.