Method for enhancing outflow of aqueous humor in treatment of glaucoma
AssigneeThe Regents of the University of California
InventorsJames D. Brandt, Martha E. O'Donnell, Fitz-Roy E. Curry
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Abstract
Elevated intra-ocular pressure is reduced by administration directly to the eye of compounds that inhibit function of a Na+—K+—2Cl−2 cotransporter mechanism discovered in trabecular meshwork cells of mammalian eyes. These compounds are useful in treatment of diseases of the eye associated with elevated intra-ocular pressure, such as ocular hypertension and glaucoma. A screening method is provided to discover additional compounds with utility for lowering intra-ocular pressure by substantially inhibiting the Na+—K+—Cl−2 cotransporter mechanism in trabecular meshwork cells.
Claims22
A method for increasing aqueous humor outflow in the eye of a mammalian patient to reduce the intra-ocular pressure therein, said method comprising administering to said eye a composition comprising an effective amount of a compound that inhibits the Na+—K+—2Cl− co-transporter in the trabecular meshwork of the eye, or a pharmaceutically acceptable salt thereof.
A method for increasing aqueous humor outflow in the eye of a mammalian patient to reduce the intra-ocular pressure therein, said method comprising administering to said eye a composition comprising an effective amount of a compound that inhibits the Na+—K+—2Cl− co-transporter in the trabecular meshwork of the eye, said compound selected from the group consisting of high ceiling diuretics.
Dependencies are inferred from the claim text.