Nucleotide analogs

A compound included for antiviral use having the formula Id

• wherein L1 is of the formula III
• wherein L2 is OR, SR or independently is L1;
• wherein n and n1 are 1;
• R is N-ethylmorpholino, pivaloyloxymethyl, phenyl, benzyl, isopropyl, t-butyl, ethyl, isopropyl, butyl, adamantoyloxymethyl, 3-methoxyphenyl, 2-carboethoxyphenyl, 4-fluorophenyl, 2,4-difluorophenyl, 3,5-dimethoxyphenyl, 2,4-dichlorophenyl, 2-ethoxyphenyl, 3-dimethylaminophenyl, 4-trifluoromethylbenzyl, 2-ethylsalicyl, —O—CH2—O—C(O)—C10H15, —C6H4—CH2—N(CH3)2, —CH2—CH2F, —CH2—CH2Cl, —CH2—CF3, —CH2—CCl3, R5, NHR6 or N(R6)2;
• wherein,
• R5 is CH2C(O)N(R6)2, CH2C(O)OR6, CH2OC(O)R6, CH(R6)OC(O)R6, CH2C(R6)2CH2OH, or CH2OR6, and
• R6 is C1-C20 alkyl which is unsubstituted or substituted by substituents independently selected from the group consisting of OH, O, N and halogen (1 to 5 halogen atoms), C6-C20 aryl which is unsubstituted or substituted by substituents independently selected from the group consisting of OH, O, N and halogen (1 to 5 halogen atoms) or C7-C20 aryl-alkyl which is unsubstituted or substituted by substituents independently selected from the group consisting of OH, O, N and halogen (1 to 5 halogen atoms);
• R1 is H, methyl, ethyl, isopropyl, phenyl or benzyl;
• R2 is H;
• R3 is H, —CH3, —CH(CH3)2, —CH2—CH(CH3)2, —CHCH3—CH2—CH3, —CH2—CH6H5, —CH2CH2—S—CH3, —CH2OH, —CH(OH)—CH3, —CH2—SH, —CH2—C6H4OH, —CH2—CO—NH2, —CH2—CH2—CO—NH2, —CH2—COOH, —CH2—CH2—COOH, —(CH2)4—NH2, —(CH2)3—NH—C(NH2)—NH2, 1-guanidinoprop-3-yl, benzyl, 4-hydroxybenzyl, imidazol-4-yl, indol-3-yl, methoxyphenyl or ethoxyphenyl;
• R4 is methyl, ethyl, propyl, isopropyl, butyl, t-butyl, phenyl, benzyl, 1-pyridyl, 3-pyridyl, 1-pyrimidinyl, pivaloyloxymethyl, N-ethylmorpholino, N-2-propylmorpholino, methoxyethyl, 4-N-methylpiperidyl, 3-N-methylpiperidyl, 1-ethylpiperazinyl 2-, 3-, and 4-N,N-dimethylaminophenyl or 2-, 3-, or 4-N,N-diethylaminophenyl;
• Z is —CH2—O—CH2—CH2—, —CH2—O—CH2—CH(CH2OH)—, —CH2—O—CH2—CH(CH2F)—, —CH2—O—CH2—CH(CH3)—, —CH2—O—CH2—CH(CH═CH2)— or —CH2—O—CH2—CH(CH2N3)—, or is of formula IV or V
• wherein
• R25 and R29 are O;
• R26 is CH;
• R27 and R28 are H;
• and
• B is adenin-9-yl, 1-deazaadenin-9-yl, 3-deazaadenin-9-yl, 7-deaza-8-azaadenin-9-yl, 8-azaadenin-9-yl, guanin-9-yl, 2,6-diaminopurin-9-yl, 2-aminopurin-9-yl, thymin-1-yl, cytosin-1-yl, 5-fluorocytosin-1-yl, 6-azacytosin-1-yl, 5-methylcytosin-1-yl, 5-bromovinyluracil-1-yl, 5-fluorouracil-1-yl or 5-trifluoromethyluracil-1-yl.