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US 6,225,303 B1Granted
Use of green porphyrins to treat neovasculature in the eye
AssigneeMassachusetts Eye and Ear Infirmary
InventorsJoan W. Miller, Evangelos S. Gragoudas
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Abstract
Photodynamic therapy of conditions of the eye characterized by unwanted neovasculature, such as age-related macular degeneration, is effective using green porphyrins as photoactive agents, preferably as liposomal compositions.
Claims20
A method of treating unwanted choroidal neovasculature in a shortened treatment time, the method comprising the steps of:
- administering to a primate subject in need of such treatment an amount of a porphyrin dye sufficient to permit an effective amount to localize in the neovasculature;
- and
- irradiating the neovasculature with light from a laser having an irradiance in the range from at least about 300 mW/cm2 to about 900 mW/cm2, the light being absorbed by the porphyrin dye so as to occlude the neovasculature.
A method of treating age-related macular degeneration in a primate subject having unwanted choroidal neovasculature in a shortened treament time, the method comprising the steps of:
- administering to the primate subject an amount of a green porphyrin dye sufficient to permit an effective amount to localize in the neovasculature;
- and
- irradiating the neovasculature with light from a laser having an irradiance in the range from at least about 300 mW/cm2 to about 900 mW/cm2, the light being absorbed by the porphyrin dye so as to occlude the neovasculature.
Dependencies are inferred from the claim text.