Pharmaceutical preparations comprised of salts of hyaluronic acid with local anaesthetics
AssigneeFidia S.p.A.
InventorsAurelio Romeo, Bruno Silvestrini, Gunter Kirschner
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Abstract
Pharmaceutical preparations are described, comprised of salts of hyaluronic acid with a basic anesthetic containing aliphatics and/or amino groups, particularly salts with benzydamine or bupivacaine.
Claims12
A medicament for topical administration comprising a stoichiometrically neutral salt of hyaluronic acid with benzydamine or bupivacaine, in which at least 50% of the carboxy groups of the hyaluronic acid are salified with the benzydamine or bupivacaine and the remaining carboxy groups are salified with an alkaline or alkaline earth metal, wherein the hyaluronic acid has a molecular weight in the range of 50-350 kDa or 500-730 kDa or 750-1,200 kDa.
Dependencies are inferred from the claim text.