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US 6,221,657 B1Granted
Modified human C3 DNA sequences and vectors
AssigneeImutran Limited
InventorsRichard Alexander Harrison, Timothy Charles Farries
Life of this patent
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Abstract
This invention is directed to DNA sequences encoding narrative complement pathway proteins modified such that the protein is capable of forming a stable C3 convertase. The modified C3 proteins are useful in therapy.
Claims10
A DNA sequence encoding a modified human C3 protein which is capable of forming a stable C3 convertase wherein said modified protein is selected from the group consisting of:
- (a) a C3 protein in which either Arg-1303, Arg-1320, or both is replaced with another amino acid;
- (b) a C3 protein which has reduced susceptibility to Factor H and/or Factor I relative to native human C3 convertase, said protein having one or more amino acid changes relative to native human C3 convertase in the region corresponding to amino acid residues 752-754 and/or residues 758-780 of native human C3 convertase;
- and
- (c) a C3 protein having amino acid changes relative to native human C3 convertase at amino acid residues 1427, 1431 and/or 1433 of native human C3 convertase.
1 more element
Dependencies are inferred from the claim text.