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US 6,221,614 B1Granted
Removal of prions from blood, plasma and other liquids
AssigneeThe Regents of the University of California
InventorsStanley B. Prusiner, Jiri G. Safar
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Abstract
Devices such as flow through columns, substrates such as spherical polymer beads, and methods of using such to remove prions from any liquid sample are disclosed. A surface of a substrate is coated with a prion complexing agent, such as a salt of phosphotungstic acid. Blood or plasma passing through a column containing beads coated with prion complexing agent are rendered prion free.
Claims9
A method of separating prions from a sample, comprising the steps of:
- contacting a sample in a flowable liquid state with a solid substrate comprised of a prion complexing agent comprised of a heteropoly acid or a salt thereof;
- allowing the sample to remain in contact with the substrate for time such that prions in the sample bind to the substrate;
- and
- separating the sample from the substrate.
1 more element
Dependencies are inferred from the claim text.