Anti-pathogen system and methods of use thereof
AssigneeWashington University
InventorSteven F. Dowdy
Life of this patent
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Abstract
The present invention provides an anti-pathogen system comprising one or more fusion proteins that includes a transduction domain and a cytotoxic domain. The cytotoxic domain is specifically activated by a pathogen infection. The anti-pathogen system effectively kills or injures cells infected by one or a combination of different pathogens. Further provided are protein transduction domains that provide enhanced transduction efficiency.
Claims21
An anti-pathogen system comprising a fusion protein comprising a covalently linked protein transduction domain and a cytotoxic domain, wherein the cytotoxic domain further comprises at least one pathogen-specific protease cleavage site.
A substantially pure fusion protein comprising a covalently linked protein transduction domain and a cytotoxic domain.
A kit comprising:
- an anti-pathogen system comprising a fusion protein which comprises a protein transduction domain for entry of the fusion protein into a cell and a cytotoxic domain that specifically produces a cytotoxin in response to infection by one or more pathogens.
Dependencies are inferred from the claim text.