Method of using deuterated calcium channel blockers
AssigneeIsotechnika Inc.
InventorRobert T. Foster
Life of this patent
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Abstract
Therapeutic methods and compositions using deuterated enriched 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic acid 3-ethyl 5-methyl ester and other deuterated dihydropyridine compounds are described. The deuterated compounds exhibit enhanced efficacy in blocking calcium channels over non-deuterated dihydropyridines.
Claims15
A method of blocking calcium channels with enhanced efficacy in an animal comprising:
- administering to an animal in need thereof, an effective amount of an enriched calcium channel blocking compound of the following structure:
- wherein R is hydrogen or deuterium and one or more R is deuterium.
A method of blocking calcium channels with enhanced efficacy in an animal comprising:
- administering to an animal in need thereof, an effective amount of an enriched calcium channel blocking compound of the following structure:
- wherein R and R1 are hydrogen or deuterium and one or more R1 is deuterium.
A method of blocking calcium channels with enhanced duration of action in an animal comprising:
- administering to an animal in need thereof, an effective amount of an enriched calcium channel blocking compound of the following structure:
- wherein R is hydrogen or deuterium and one or more R is deuterium.
A method of blocking calcium channels with enhanced duration of action in an animal comprising:
- administering to an animal in need thereof, an effective amount of an enriched calcium channel blocking compound of the following structure:
- wherein R and R1 are hydrogen or deuterium and one or more R1 is deuterium.
A method of blocking calcium channel with enhanced use dependence in an animal comprising:
- administering to an animal in need thereof, an effective amount of an enriched calcium channel blocking compound of the following structure:
- wherein R is hydrogen or deuterium and one or more R is deuterium.
A method of blocking calcium channels with enhanced use dependence in an animal comprising:
- administering to an animal in need thereof, an effective amount of an enriched calcium channel blocking compound of the following structure:
- wherein R and R1 are hydrogen or deuterium and one or more R1 is deuterium.
A method of treating hypertension with enhanced efficacy in an animal comprising:
- administering to an animal in need thereof, an effective amount of an enriched calcium channel blocking compound of the following structure:
- wherein R is hydrogen or deuterium and one or more R is deuterium.
A method of treating hypertension with enhanced efficacy in an animal comprising:
- administering to an animal in need thereof, an effective amount of an enriched calcium channel blocking compound of the following structure:
- wherein R and R1 are hydrogen or deuterium and one or more R1 is deuterium.
A method of treating hypertension with an extended duration of action in an animal comprising:
- administering to an animal in need thereof, an effective amount of an enriched calcium channel blocking compound of the following structure:
- wherein R is hydrogen or deuterium and one or more R is deuterium.
A method of treating hypertension with an extended duration of action in an animal comprising:
- administering to an animal in need thereof, an effective amount of an enriched calcium channel blocking compound of the following structure:
- wherein R and R1 are hydrogen or deuterium and one or more R1 is deuterium.
Dependencies are inferred from the claim text.