Method for producing large crystals of complex molecules
OwnerTrevor Percival Castor, Matthew Albert Britz +3inventors
InventorsTrevor Percival Castor, Matthew Albert Britz, Maury David Cosman, Peter Richard d'Entremont, Glenn Thomas Hong
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Abstract
Compressed gases, liquefied gases, or supercritical fluids are utilized as anti-solvents in a crystal growing process for complex molecules. Crystals of the present invention exhibit greater crystal size and improved morphology over crystals obtained by conventional methods.
Claims15
A method for forming crystals of compositions selected from the group consisting of taxoids and brystatins comprising the steps:
- (a.) providing a compound of 90-100% purity selected from the group consisting of taxoids and brystatins, and dissolving said compound in a solvent to form a first solution,
- (b.) combining said first solution with a critical, supercritical or near critical fluid to form a second solution comprising said fluid, solvent and said compound, said second solution having a concentration of said compound 5 to 1000 times the solubility of said compound;
- and,
- (c.) allowing said compound to precipitate out of said second solution as crystals with a minimum dimension of 25 to 100 microns and harvesting the crystals formed wherein said crystals do not exhibit needle-like habit.
A method for forming crystals of compositions selected from the group consisting of taxoids and brystatins comprising the steps:
- (a.) providing a compound of 90-100% purity, said compound selected from the group consisting of taxoids and brystatins and dissolving said compound in a solvent to form a first solution,
- (b.) combining said first solution with a solvent to form a second solution comprising said fluid, solvent and said compound, said solvent selected from the group of solvents consisting of acetone, methanol, ethanol, butanol, tetrahydrofuran, methylene chloride, chloroform, toluene, dimethylsulfoxide, N, N, dimethylformamide, cyclohexanone, butyrolactone, water and combinations of two or more of this group;
- (c.) said second solution having a concentration of said compound 5 to 1000 times the solubility of said compound;
- and,
- (d.) allowing said compound to precipitate out of said second solution as crystals with a minimum dimension of 25 to 100 microns and harvesting the crystals formed wherein said crystals do not exhibit needle-like habit.
A method for forming paclitaxel crystals comprising the steps:
- (a.) providing paclitaxel of 90-100% purity, and dissolving said paclitaxel in a solvent to form a first solution,
- (b.) combining said first solution with a critical, supercritical or near critical fluid to form a second solution comprising said fluid, solvent and said paclitaxel, said second solution having a concentration of paclitaxel 5 to 1000 times the solubility of paclitaxel;
- and,
- (c.) allowing paclitaxel to precipitate out of said second solution as crystals with a minimum dimension of 25 to 100 microns and harvesting the crystals formed wherein said crystals do not exhibit needle-like habit.
A method for forming paclitaxel crystals comprising the steps:
- (a.) providing paclitaxel of 90-100% purity, and dissolving said paclitaxel in a solvent consisting essentially of acetone to form a first solution,
- (b.) combining said first solution with a critical, supercritical or near critical fluid to form a second solution comprising said fluid, solvent and said paclitaxel, said second solution having a concentration of paclitaxel 5 to 1000 times the solubility of paclitaxel;
- and,
- (c.) allowing paclitaxel to precipitate out of said second solution as crystals with a minimum dimension of 25 to 100 microns and harvesting the crystals formed wherein said crystals do not exhibit needle-like habit.
Dependencies are inferred from the claim text.