Device and method for enchancing transdermal sampling
AssigneeAlza Corporation
InventorsMichel J. N. Cormier, Felix T. Theeuwes
Life of this patent
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Abstract
A percutaneous agent sampling device and method are provided. The device comprises a collector and a sheet having a plurality of microblades for piercing the skin for increasing transdermal flux of an agent.
Claims28
A device for piercing the stratum corneum of a body surface to form pathways through which an agent can be withdrawn, comprising:
- a sheet having a plurality of microblades formed from the sheet and bent downward therefrom and at least one opening in the sheet adjacent the plurality of microblades;
- and
- a collector on the sheet which withdraws the agent through the pathways and collects said agent.
A method for transdermally sampling an agent contained in the body of a patient, comprising:
- providing a sheet having at least one opening adjacent a plurality of microblades, said microblades formed from the sheet and bent downward therefrom;
- forming a plurality of microslits through a stratum corneum of skin of the patient by placing on the skin the sheet to cause said microblades to pierce the stratum corneum;
- and
- withdrawing the agent through the microslits and collecting the agent in a reservoir.
A device for piercing the stratum corneum of a body surface to form pathways through which an agent can be withdrawn, comprising:
- a sheet having at least one opening adjacent a plurality of microblades extending from the sheet;
- and
- a passive diffusion device on the sheet which collects the agent withdrawn through the pathways.
A device for piercing the stratum corneum of a body surface to form pathways through which an agent can be withdrawn, comprising:
- a sheet having at least one opening adjacent a plurality of microblades extending from the sheet;
- and
- an osmotic device on the sheet which collects the agent withdrawn through the pathways.
A device for piercing the stratum corneum of a body surface to form pathways through which an agent can be withdrawn, comprising:
- a sheet forming at least one opening adjacent a plurality of microblades extending from the sheet;
- and
- a reverse electrotransport device on the sheet which collects the agent withdrawn through the pathways.
Dependencies are inferred from the claim text.