Lubricious, drug-accommodating coating
AssigneeMedtronic AVE, Inc.
InventorsEugene Tedeschi, Chirag B. Shah
Life of this patent
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Abstract
A coating is provided for a substrate comprising a polyisocyanate; an amine donor and/or hydroxyl donor; an isocyanatosilane adduct having terminal isocyanate groups and at least one hydrolyzable alkoxy group bonded to silicon; and optionally a polymer selected from the group consisting of polyethylene oxide, polyvinyl pyrrolidone, polyvinyl alcohol, polyethylene glycol, and polyacrylic acid. The coating can accommodate a drug so that when the coating is applied to a medical device, the medical device becomes drug-releasing when in contact with aqueous body fluid. A coated article as well as a method for preparing the coating is also provided.
Claims38
A drug-releasing coating, comprising:
- at least one drug associated with and releasable from a polyurea network formed from the reaction on a substrate to be coated of a mixture comprising:
- (a) a polyisocyanate;
- (b) an amine;
- (c) an isocyanatosilane adduct having at least one terminal isocyanate group and at least one hydrolyzable alkoxy group bonded to silicon;
- and optionally
- (d) a polymer selected from the group consisting of polyethylene oxide, polyvinyl pyrrolidone, polyvinyl alcohol, polyethylene glycol, and polyacrylic acid.
An article, comprising (1) a substrate on which is coated (2) a drug-releasing coating, comprising:
- at least one drug associated with and releasable from a polyurea network formed from reaction on a substrate to be coated of a mixture comprising:
- (a) a polyisocyanate;
- (b) an amine donor;
- (c) an isocyanatosilane adduct having at least one terminal isocyanate group and at least one hydrolyzable alkoxy group bonded to silicon;
- and optionally
- (b) a polymer selected from the group consisting of a polyethylene oxide, polyvinyl pyrrolidone, polyvinyl alcohol, polyethylene glycol, and polyacrylic acid.
A method of preparing a drug-releasing coating on a substrate to be coated comprising:
- (a) forming a mixture of a polyisocyanate;
- an amine;
- an isocyanatosilane adduct having at least one terminal isocyanate group and at least one hydrolyzable alkoxy group bonded to silicon;
- and optionally a polymer selected from the group consisting of polyethylene oxide, polyvinyl pyrrolidone, polyvinyl alcohol, polyethylene glycol, and polyacrylic acid, in a solvent;
- (b) applying said mixture to said substrate;
- (c) associating a drug with said mixture-applied substrate by contacting said mixture-applied substrate with a drug;
- and
- (d) curing said mixture on said substrate to form said coating.
In a medical device having a drug-releasing coating, the improvement comprising:
- a drug-releasing functional group associated with and releaseable from a polyurea network formed by the reaction of a mixture comprising:
- (a) a polyisocyanate;
- (b) an amine;
- and
- (c) an isocyanatosilane adduct having terminal isocyanate groups and at least one hydrolyzable alkoxy group bonded to silicon;
- and optionally
- (d) a polymer selected from the group consisting of polyethylene oxide, polyvinyl pyrrolidone, polyvinyl alcohol, polyethylene glycol, and polyacrylic acid.
Dependencies are inferred from the claim text.