Materials and methods for making improved micelle compositions
AssigneeThe Board of Trustees of the University of Illinois
InventorsHayat Önyüksel, Israel Rubinstein
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Abstract
Provided are methods for preparing improved biologically active micelle and crystalline products comprising a biologically active amphipathic compound in association with a micelle or crystalline product. Methods for producing the micelle or crystalline products as well as methods of using the micelle or crystalline products in therapeutic, diagnostic, and cosmetic, applications are also provided.
Claims34
A method of preparing a biologically active micelle product comprising one or more biologically active amphipathic compounds in association with a micelle;
- said method comprising the steps of:
- a) mixing one or more lipids wherein at least one lipid component is covalently bonded to a water-soluble polymer;
- b) forming sterically stabilized micelles from lipids;
- c) incubating micelles from step (b) with one or more biologically active amphipathic compound(s) under conditions in which said compound(s) becomes associated with said micelles in a more biologically active conformation.
A method of preparing a biologically active micelle product comprising one or more biologically active amphipathic compounds in association with a micelle;
- said method comprising the steps of:
- a) mixing one or more lipids with one or more biologically active amphipathic compounds, wherein at least one lipid component is covalently bonded to a water-soluble polymer;
- b) forming sterically stabilized micelles from the mixture of step (a) under conditions in which said compound(s) becomes associated with said micelles in a more biologically active conformation.
A method for preparing a biologically active sterically stabilized crystalline product comprising one or more biologically active compounds which are insoluble in aqueous solution;
- said method comprising the steps of:
- a) mixing the biologically active compound(s) with one or more lipids, wherein at least one of the lipids is conjugated to a water soluble polymer;
- and
- b) forming sterically stabilized crystalline products.
Dependencies are inferred from the claim text.