Inhibitors of lipoxygenase
AssigneeOryza Oil & Fat Chemical Co., Ltd.
InventorsHiromichi Murai, Tadashi Okada, Hiroyo Yamamoto
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Abstract
Novel inhibitors of the enzyme action of lipoxygenase, especially 5-lipoxygenase and 12-lipoxygenase that are derived from the extraction of the seeds of the perilla (crispa) or perilla (frutescens) plant. These inhibitors are suitably extracted from these seeds using alcohol, preferably ethanol, to form an extract or more preferably to further extract the alcoholic extract with ethyl acetate and water to partition the active inhibitors to the ethyl acetate. The particularly preferred inhibitors are luteolin and chrysoeriol.
Claims24
A composition comprising a sufficient amount of an ethanol extract of perilla seed, comprising at least one compound selected from the group consisting of luteolin, chrysoeriol, rosemarinic acid, rosemarinic acid methyl ester and apigenin, effective to inhibit the enzyme action of lipoxygenase.
A method of combating allergic reaction and inflammatory responses which comprises administering, to an animal having an allergic reaction, an inhibitor of the enzyme action of lipoxygenase comprising an ethanol extract of perilla seed, comprising an amount of at least one compound selected from the group consisting of luteolin, chrysoeriol, rosemarinic acid, rosemarinic acid methyl ester and apigenin, effective to inhibit the enzyme action of lipoxygenase.
A method of combating allergic reaction and inflammatory responses which comprises administering, to an animal having an allergic reaction, an inhibitor of the enzyme action of lipoxygenase comprising an ethyl acetate extract of perilla seeds comprising an amount of at least one compound selected from the group consisting of luteolin, chrysoeriol, rosemarinic acid, rosemarinic acid methyl ester and apigenin, effective to inhibit the enzyme action of lipoxygenase.
A method of inhibiting the enzyme action of lipoxygenase that comprises administering to an animal in need thereof an effective amount of an ethanol or ethyl acetate extract of perilla seed comprising at least luteolin and chrysoeriol.
A composition comprising an ethanol extract of perilla seed.
Dependencies are inferred from the claim text.