Ribonuclease resistant RNA preparation and utilization
OwnerBrittan L. Pasloske, Dwight DuBois +2inventors
InventorsBrittan L. Pasloske, Dwight DuBois, David Brown, Matthew Winkler
Life of this patent
Estimating the term…
Abstract
The present invention relates to nuclease resistant nucleic acids in general and ribonuclease resistant RNAs in particular. Methods of making and using such nucleic acids are disclosed.
Claims62
An RNA detection and/or quantification standard comprising a recombinant RNA segment encapsidated in viral coat protein, wherein said recombinant RNA segment comprises a sequence adapted for use as a standard in the detection and/or quantification of human immunodeficiency virus (HIV), hepatitis C virus (HCV), or enterovirus, wherein the RNA standard is resistant to ribonuclease.
An RNA detection and/or quantification standard comprising a recombinant RNA segment encapsidated in a bacteriophage viral coat protein, wherein said recombinant RNA segment comprises a sequence adapted for use as a standard in the detection and/or quantification of HIV, wherein the RNA standard is resistant to ribonuclease.
An RNA detection and/or quantification standard comprising a recombinant RNA segment encapsidated in a bacteriophagc viral coat protein, wherein said recombinant RNA segment comprises a sequence adapted for use as a standard in the detection and/or quantification of HCV, wherein the RNA standard is resistant to ribonuclease.
An RNA detection and/or quantification standard comprising a recombinant RNA segment encapsidated in a bacteriophage viral coat protein, wherein said recombinant RNA segment comprises a sequence adapted for use as a standard in the detection and/or quantification of enterovirus, wherein the RNA standard is resistant to ribonuclease.
Dependencies are inferred from the claim text.