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US 6,214,888 B1Granted
Dermatological compounds
AssigneeApplied Genetics, Inc.
InventorsWu Yun Ren, David A. Brown
Life of this patent
Estimating the term…
Abstract
The present invention relates to novel monocyclic and bicyclic monoterpene diols that stimulate melanogenesis in mammalian skin, hair, wool or fur, and, are useful for treating or preventing various skin and proliferative disorders, neurodegenerative diseases, and diseases regulated by the nitric oxide/cyclic GMP/protein kinase G pathway.
Claims19
A compound selected from the group consisting of:
- (a) (−)-2,2-dimethyl-3-hydroxy-3-hydroxymethyl-norbornane;
- (b) derivatives of (−)-2,2-dimethyl-3-hydroxy-3-hydroxymethyl-norbornane;
- (c) (+)-2,2-dimethyl-3-hydroxy-3-hydroxymethyl-norbornane;
- (d) derivatives of (+)-2,2-dimethyl-3-hydroxy-3-hydroxymethyl-norbornane;
- (e) (−)-2,2-dimethyl-3-(2,3-dihydroxy-propan-3-yl)-norbornane;
- (f) derivatives of (−)-2,2-dimethyl-3-(2,3-dihydroxy-propan-3-yl)-norbornane;
- (g) (+)-2,2-dimethyl-3-(2,3-dihydroxy-propan-3-yl)-norbornane;
- and
- (h) derivatives of (+)-2,2-dimethyl-3-(2,3-dihydroxy-propan-3-yl)-norbornane.
6 more elements
A compound selected from the group consisting of:
- (a) (−)-2,2-dimethyl-3-hydroxy-3-hydroxymethyl-norbornane;
- (b) derivatives of (−)-2,2-dimethyl-3-hydroxy-3-hydroxymethyl-norbornane;
- (c) (+)-2,2-dimethyl-3-hydroxy-3-hydroxymethyl-norbornane;
- and
- (d) derivatives of (+)-2,2-dimethyl-3-hydroxy-3-hydroxymethyl-norbornane.
2 more elements
A compound selected from the group consisting of:
- (a) (+)-2,2-dimethyl-3-hydroxy-3-hydroxymethyl-norbornane;
- and
- (b) derivatives of (+)-2,2-dimethyl-3-hydroxy-3-hydroxymethyl-norbornane.
A compound selected from the group consisting of:
- (a) (−)-2,2-dimethyl-3-(2,3-dihydroxy-propan-3-yl)-norbornane;
- (b) derivatives of (−)-2,2-dimethyl-3-(2,3-dihydroxy-propan-3-yl)-norbornane;
- (c) (+)-2,2-dimethyl-3-(2,3-dihydroxy-propan-3-yl)-norbornane;
- and
- (d) derivatives of (+)-2,2-dimethyl-3-(2,3-dihydroxy-propan-3-yl)-norbornane.
2 more elements
A compound selected from the group consisting of:
- (a) (−)-2,2-dimethyl-3-(2,3-dihydroxy-propan-3-yl)-norbornane;
- and
- (b) derivatives of (−)-2,2-dimethyl-3-(2,3-dihydroxy-propan-3-yl)-norbornane.
Dependencies are inferred from the claim text.