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US 6,214,872 B1Granted
Aryloxyarylsulfonylamino hydroxamic acid derivatives
AssigneePfizer Inc.
InventorRalph Pelton Robinson
Life of this patent
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Abstract
A compound of the formula wherein X, Y, R1 and R2 are as defined above, useful in the treatment of arthritis or cancer and other diseases involving selective inhibition of matrix metaloproteinase-13.
Claims15
A compound of the formula
- or the pharmaceutically acceptable salts thereof, wherein
- R1 is (C1-C6)alkyl;
- R2 is (C1-C6)alkyl;
- or R1 and R2 taken together with the carbon atom to which they are attached form a ring selected from (C5-C7)cycloalkyl, 4-tetrahydropyranyl and 4-piperidinyl;
- R3 is hydrogen or (C1-C6)alkyl;
- and
- Y is a substituent on any of the carbon atoms of the phenyl ring capable of supporting an additional bond, independently selected from fluoro, chloro, trifluoromethyl, (C1-C6)alkoxy, trifluoromethoxy, difluoromethoxy and (C1-C6)alkyl.
4 more elements
Dependencies are inferred from the claim text.