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US 6,214,846 B1Granted
Substituted 3-(benzylamino)piperidine derivatives and their use as therapeutic agents
AssigneeMerck Sharp & Dohme Corp.
InventorJason Matthew Elliott
Life of this patent
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Abstract
The present invention relates to compounds of formula (I), wherein R1 represents a fluoroC1-2alkoxy group; and R2 represents a hydrogen or halogen atom or a C1-4alkyl, C1-4alkoxy, fluoroC1-4alkyl or fluoroC1-4alkoxy group; or a pharmaceutically acceptable salt thereof. The compounds are of particular use in the treatment or prevention of pain or inflammation, migraine, emesis, postherpetic neuralgia, depression or anxiety.
Claims9
A compound of the formula (I):
- wherein
- R1 represents a fluoroC1-2alkoxy group;
- and
- R2 represents a hydrogen or halogen atom or a C1-4alkyl, C1-4alkoxy, fluoroC1-4alkyl or fluoroC1-4alkoxy group;
- or a pharmaceutically acceptable salt thereof.
2 more elements
A compound which is selected from:
- N-{[2-cyclopropoxy-5-(trifluoromethoxy)phenyl]methyl}-2-phenylpiperidin-3-amine;
- (2S,3S)-N-{[2-cyclopropoxy-5-(trifluoromethoxy)phenyl]methyl}-2-phenylpiperidin-3-amine;
- N-{[2-cyclopropoxy-5-(trifluoromethoxy)phenyl]methyl}-2-(4-fluorophenyl)piperidin-3-amine;
- or a pharmaceutically acceptable salt thereof.
1 more element
Dependencies are inferred from the claim text.