Neo-tryptophan

An amino acid, wherein said amino acid is neo-tryptophan.

A composition, said composition comprising a compound having the following structure:

• wherein R1, R2, and R3 independently are H, OH, CH3, SH, F, NH2, or COOH, and A is two or three.

A composition, said composition comprising a compound having the following structure:

• wherein R1 is a hydroxyl group, R2 is an amino group, R3 is a hydroxyl group, and A is zero.

A method of synthesizing neo-tryptophan, said method comprising:

• a) providing 4-hydroxymethyl indole, wherein the N-1 nitrogen of said 4-hydroxymethyl indole is protected by a protecting group, wherein said protecting group comprises Boc,
• b) substituting the hydroxyl group of said 4-hydroxymethyl indole with a glycyl unit, and
• c) removing said protecting group after said substitution to produce neo-tryptophan.

A method of synthesizing a neo-tryptophan derivative, said method comprising:

• a) providing 4-hydroxymethyl indole, wherein the N-1nitrogen of said 4-hydroxymethyl indole is protected by a protecting group, wherein said protecting group comprises Boc, and
• b) substituting the hydroxyl group of said 4-hydroxymethyl indole with a glycyl unit to produce a neo-tryptophan derivative.

A method of synthesizing a neo-tryptophan derivative, said method comprising:

• a) providing 4-hydroxymethyl indole, wherein the N-1nitrogen of said 4-hydroxymethyl indole is protected by a protecting group,
• b) substituting the hydroxyl group of said 4-hydroxymethyl indole with a glycyl unit, and
• c) adding an additional protecting group to the nitrogen within said glycyl unit to produce a neo-tryptophan derivative, wherein said additional protecting group comprises Fmoc.

A method of making a polypeptide containing neo-tryptophan, said method comprising:

• a) providing a neo-tryptophan derivative, and
• b) linking an amino acid residue to said neo-tryptophan derivative to form said polypeptide containing neo-tryptophan.

A method of inducing a neurotensin response in a mammal, said method comprising administering an effective dose of a polypeptide to said mammal, wherein said polypeptide comprises neo-tryptophan.

A method of treating a mammal having a serotonin recognition molecule, said method comprising administering a composition to said mammal, wherein said composition interacts with said sertonin recognition molecule, said composition comprising neo-tryptophan.

A method for screening a polypeptide for in vivo use, said method comprising:

• a) contacting a polypeptide with a protease, wherein said polypeptide contains neo-tryptophan, and
• b) determining whether or not said polypeptide remains intact.

A composition, wherein said composition comprises neo-tryptophan.

A composition, wherein said composition comprises neo-tryptophan having a blocking group, wherein said blocking group comprises Fmoc.

A composition, wherein said composition comprises neo-tryptophan having a blocking group, wherein said blocking group comprises Boc.

A composition, said composition comprising a compound having the following structure:

• wherein R1 and R2 independently are H, OH, CH3, SH, F, NH2, or COOH, R3 is H, CH3, SH, F, NH2, or COOH, and A is zero.

A composition, said composition comprising a compound having the following structure:

• wherein R1 is OH, CH3, SH, F, NH2, or COOH, R2 is OH, SH, or F, R3 is OH, and A is zero.

A composition, said composition comprising a compound having the following structure:

• wherein R1 is H, OH, SH, F, NH2, or COOH, R2 is OH, SH, or F, R3 is OH, and A is zero.

A composition, said composition comprising a compound having the following structure:

• wherein R1 is H, OH, CH3, SH, F, or COOH, R2 is H, OH, CH3, SH, F, or COOH, R3 is OH, and A is zero.

A composition, said composition comprising a compound having the following structure:

• wherein R1 is H, OH, CH3, SH, F, or NH2, R2 is OH, SH, or F, R3 is OH, and A is zero.

A method of treating a mammal having a serotonin recognition molecule, said method comprising administering a composition to said mammal, wherein said composition interacts with said serotonin recognition molecule, said composition comprising a compound having the following structure:

• wherein R1, R2, and R3 independently are H, OH, CH3, SH, F, NH2, or COOH, and A is one, two, or three.

A method of treating a mammal having a serotonin recognition molecule, said method comprising administering a composition to said mammal, wherein said composition interacts with said serotonin recognition molecule, said composition comprising a compound having the following structure:

• wherein R1 and R2 independently are H, OH, CH3, SH, F, NH2, or COOH, R3 is H, CH3, SH, F, NH2, or COOH, and A is zero.

A method of treating a mammal having a serotonin recognition molecule, said method comprising administering a composition to said mammal, wherein said composition interacts with said serotonin recognition molecule, said composition comprising a compound having the following structure:

• wherein R1 is OH, CH3, SH, F, NH2, or COOH, R2 is OH, SH, or F, R3 is OH, and A is zero.

A method of treating a mammal having a serotonin recognition molecule, said method comprising administering a composition to said mammal, wherein said composition interacts with said serotonin recognition molecule, said composition comprising a compound having the following structure:

• wherein R1 is H, OH, SH, F, NH2, or COOH, R2 is OH, SH, or F, R3 is OH, and A is zero.

A method of treating a mammal having a serotonin recognition molecule, said method comprising administering a composition to said mammal, wherein said composition interacts with said serotonin recognition molecule, said composition comprising a compound having the following structure:

• wherein R1 is H, OH, CH3, SH, F, or COOH, R2 is H, OH, CH3, SH, F, or COOH, R3 is OH, and A is zero.

A method of treating a mammal having a serotonin recognition molecule, said method comprising administering a composition to said mammal, wherein said composition interacts with said serotonin recognition molecule, said composition comprising a compound having the following structure:

• wherein R1 is H, OH, CH3, SH, F, or NH2, R2 is OH, SH, or F, R3 is OH, and A is zero.

A composition, said composition comprising a compound having the following structure:

• wherein R1 is H, OH, CH3, SH, F, or COOH, R2 is H, OH, CH3, SH, F, NH2 or COOH, R3 is H, OH, CH3, SH, F, NH2 or COOH, and A is one.

A composition, said composition comprising a compound having the following structure:

• wherein R1 is H, OH, CH3, SH, F, NH2 or COOH, R2 is OH, CH3, SH, F, NH2 or COOH, R3 is H, OH, CH3, SH, F, NH2 or COOH, and A is one.

A composition, said composition comprising a compound having the following structure:

• wherein R1 is H, OH, CH3, SH, F, NH2 or COOH, R2 is H, OH, CH3, SH, F, NH2 or COOH, R3 is H, CH3, SH, F, NH2 or COOH, and A is one.