Mesenchymal stem cells for cartilage repair
AssigneeMorphoGen Pharmaceuticals, Inc.
InventorsDaniel A. Grande, Paul A. Lucas
Life of this patent
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Abstract
It has been discovered that mesenchymal stem cells (MSCs) in a polymeric carrier implanted into a cartilage and/or bone defect will differentiate to form cartilage and/or bone, as appropriate. Suitable polymeric carriers include porous meshes or sponges formed of synthetic or natural polymers, as well as polymer solutions. A presently preferred material is a polyglycolic acid mesh.
Claims17
A composition for growing new cartilage and or bone in a patient comprising
- mesenchymal stem cells in a polymeric carrier suitable for proliferation and differentiation of the cells into cartilage and or bone.
A composition for growing new mixed connective tissue comprising mesenchymal cells in a polymeric carrier suitable for implantation in a fascial plane formed of muscle cells, fat, fibroblasts, and cartilage.
A composition for growing new articular cartilage or articular cartilage and subchondral bone in a patient comprising an effective amount of
- isolated mesenchymal stem cells seeded in a polymeric carrier suitable for proliferation and differentiation of the cells into articular cartilage or articular cartilage and subchondral bone.
A composition for growing new articular cartilage or articular cart and subchondral bone in a patient comprising an effective amount of
- isolated mesenchymal stem cells seeded in a polymeric carrier suitable for proliferation and differentiation of the cells into articular cartilage or articular cartilage and subchondral bone,
- wherein said isolated mesenchymal stem cells are purified pluripotent mesenchymal stem cells, which cells are characterized the being substantially free of multinucleated myogenic lineage-committed cells, and which cells are predominantly stellate-shaped cells, wherein the mesenchymal stem cells form predominantly fibroblastic cells when contacted with muscle morphogenic protein in tissue couture medium containing 10% fetal calf serum and form predominantly branched multinucleated structures that spontaneously contract when contacted with muscle morphogenic protein and scar inhibitory factor in tissue culture with medium containing 10% fetal calf serum.
Dependencies are inferred from the claim text.