Bone substitution material and a method of its manufacture
AssigneeEtex Corporation
InventorsDosuk D. Lee, Christian Rey, Maria Aiolova
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Abstract
The present invention provides a novel process for converting a standard inert amorphous calcium phosphate precipitate into highly reactive amorphous solids. The amorphous solids can be used to react with other calcium phosphate solids to form a poorly-crystalline synthetic hydroxyapatite that provides both bioactivity and structural integrity. This novel amorphous material can be reacted with other calcium phosphates at or below 37° C. to form a bone-like material consisting of poorly crystalline hydroxyapatite.
Claims21
A formable paste, suitable for use as a bone substitution material, comprising:
- a powder comprising a first calcium phosphate material having at least 90% amorphous character and an acidic second calcium phosphate material, the powder having a calcium to phosphorous molar ratio in the range of about 1.2 to 1.68;
- and
- a fluid in an amount to provide a formable or injectable consistency, said paste remaining injectable or formable for a time greater than about 60 minutes at about 22° C. and hardenable within about 30 minutes at about 37° C., said paste suitable for use as a bone substitute material.
A method of promoting bone growth, comprising:
- providing a paste, said paste comprising a calcium phosphate powder, said powder comprising a first calcium phosphate material having at least 90% amorphous character and an acidic second calcium phoshate material the powder having a calcium to phosphorous molar ratio in the range of about 1.2 to 1.68, and a fluid in an amount which provides a formable or injectable consistency, said paste remaining injectable or formable for a time greater than about 60 minutes at about 22° C.;
- applying the paste to a site requiring bone growth:
- and allowing the paste to harden at the site within about 30 minutes.
Dependencies are inferred from the claim text.