Process for the preparation of phenyl alkyl ketones and benzaldehydes
AssigneeBayer Aktiengesellschaft
InventorsArthur Wegmann, Terry Lee Moore, Linhua Wang
Life of this patent
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Abstract
There is provided a process for the preparation of compounds of formula I wherein: X is H or F, Y is CF3 or F and R1 is hydrogen or C1-C2alkyl; in which process (1) a compound of formula II, wherein X and Y are as defined for formula I, is reacted with an organic or inorganic nitrite or nitrous acid; (2) the resulting diazonium compound of formula III is reacted with an aldoxime of formula V R1—CH═NOH (V) wherein R1 is as defined for formula I, in presence of CuSO4; and (3) the resulting oxime of formula IV is hydrolyzed with aqueous acid to the compound of formula I.
Claims11
A process for the preparation of a compound of formula I
- wherein:
- X is H or F,
- Y is CF3 or F and
- R1 is C1-C2alkyl;
- in which process
- (1) a compound of formula II, wherein X and Y are as defined for formula I, is reacted with (i) an organic nitrite in an organic solvent;
- or (ii) nitrous acid or a salt thereof in aqueous solution, in the presence of an acid selected from the group consisting of sulfuric acid and nitrosulfuric acid;
- (2) the resulting diazonium compound of formula III is reacted with an aldoxime of formula V
- R1—CH═NOH (V)
- wherein R1 is as defined for formula I, in the presence of CuSO4 and a hydrophobic solvent;
- and
- (3) the resulting oxime of formula IV is hydrolyzed with aqueous acid to the compound of formula I.
Dependencies are inferred from the claim text.