Methods for the acylation of amine compounds
AssigneeNovartis Pharmaceuticals Corporation
InventorsJohn Joseph Fitt, Sr., Prasad Koteswara Kapa
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Abstract
Method for the acylation of amines are disclosed in which includes reacting a first reactant containing an amine group with a second reactant containing an acyl halide group, wherein the reaction takes place in the presence of secondary carboxylic acid salt form, of formula I: R4R5CHCOOH I wherein R4 is an alkyl group having 1 to 10 carbon atoms; and R5 is an alkyl group having 1 to 10 carbon atoms.
Claims14
A method for the acylation of an amine in which the method comprises reacting a first reactant containing an amine group with a second reactant containing an acyl halide group, wherein the reaction takes place in the presence of a secondary carboxylic acid of formula I:
- R4R5CHCOOH I
- wherein
- R4 is an alkyl group having 1 to 10 carbon atoms;
- and
- R5 is an alkyl group having 1 to 10 carbon atoms.
The method of claim l, wherein the first reactant and the secondary carboxylic acid are combined with each other prior to combination with the second reactant.
Dependencies are inferred from the claim text.