8-hydroxy-7-substituted quinolines as anti-viral agents

A compound of the formula III

• wherein R1 is
• a) —H,
• b) —C1-C5 alkyl, or
• c) —CH═CH-aryl;
• wherein R2 is
• a) —C1-C10 alkyl,
• b) —(CH2)nR3,
• c) —CH(R4)R3, or
• d) —(CH2)n—X2—R3;
• wherein R3 is
• a) -aryl,
• b) -het substituted by zero (0) to two (2) R5, or
• c) —C3-C6 cycloalkyl;
• wherein R4 is
• a) —C1-C5 alkyl, or
• b) -aryl;
• wherein X1 is
• a) —H,
• b) —F,
• c) —Cl,
• d) —Br, or
• e) —I;
• wherein X2 is
• a) —O—;
• b) —S—, or
• c) —NH—;
• where n is zero (0) to four (4) inclusive;
• wherein aryl is
• a) phenyl substituted by zero (0) to two (2) R5, or
• b) naphthyl substituted by zero (0) to two (2) R5;
• wherein het is a 5- or 6-membered saturated or unsaturated ring containing from one (1) to three (3) heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur;
• optionally, het is fused to a benzene ring;
• and the ring can be connected through a carbon or a nitrogen in the ring;
• wherein R5 is
• a) —H,
• b( —CH1-C5 alkyl,
• c) —F,
• d) —Cl,
• e) —OCH3,
• f) —CF3,
• g) —NHSO2-het substituted by zero (0) to two (2) —C1-C5 alkyl, or
• h) —NHSO2-phenyl;
• or a pharmaceutically acceptable salt thereof.