Pharmaceutical compositions and methods for use
OwnerPeter Anthony Crooks, Niranjan Madhukar Deoinventors
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Abstract
A compound of the formula: wherein X′ is nitrogen or carbon bonded to a substituent species characterized as having a sigma m value greater than 0, less than 0 or 0; X is nitrogen or carbon bonded to a substituent species characterized as having a sigma m value equal to 0; A, A′ and A″ are individually substituent species characterized as having a sigma m value greater than 0, less than 0 or 0; Z′ is a substituent other than hydrogen; j is an integer from 0 to 5; and the wavy line in the structure indicates that the compound can exist in the form of an enantiomer or a diasteromer; Z″ is hydrogen or a substituent other than hydrogen; Y is C═O, C(OH)R′ or C—A, where R′ is hydrogen or lower alkyl is provided.
Claims8
A compound of the formula:
- wherein X′ is nitrogen X is nitrogen or carbon bonded to a substituent species characterized as having a sigma m value between −0.3 and 0.75;
- A, A′ and A″ are individually selected substituent species characterized as having a sigma m value between −0.3 and 0.75;
- and the wavy line in the structure indicates that the compound can exist in the form of an enantiomer or diastereomer;
- Y is C═O, C(OH)R′ or C—A, where R′ is hydrogen or lower alkyl.
A compound of the formula:
- wherein:
- X′ is nitrogen;
- X is carbon bonded to a substituent selected from the group consisting of H, F, Br, I, R′, NR′R″, CF3, OH, CN, NO2, C2R′, SH, SCH3, N3, SO2CH3, OR′, SR′, C(═O)NR′R″, NR′C(═O)R′, C(═O)R′, C(═O)OR′, (CH2)qOR′, OC(═O)R′, OC(═O)NR′R″, and NR′C(═O)OR′;
- A, A′, and A″ are independently selected from the group consisting of H, F, Br, I, R′, NR′R″, CF3, OH, CN, NO2, C2R′, SH, SCH3, N3, SO2CH3, OR′, SR′, C(═O)NR′R″, NR′C(═O)R′, C(═O)R′, C(═O)OR′, (CH2)qOR′, OC(═O)R′, OC(═O)NR′R″, and NR′C(═O)OR′;
- Y is C═O, C(OH)R′″ or C—A;
- R′ and R″ are individually selected from the group consisting of hydrogen, C1-C10 alkyl, C1, or C2;
- R′″ is H or C1 to C10 alkyl;
- q is from 1-6;
- and
- the wavy line in the structure indicates that the compound can exist in the form of an enantiomer or a diastereomer.
Dependencies are inferred from the claim text.