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US 6,211,355 B1Granted
Radionuclide labeling of vitamin B12 and coenzymes thereof
AssigneesMayo Foundation for Medical Education and Research, Regents of the University of Minnesota
InventorsDouglas A. Collins, Henricus Petrus Hogenkamp
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Abstract
A compound useful for in vivo imaging of organs and tumors is provided of formula: wherein is a cobalamin, is derived from a corrin carboxylic acid group of said cobalamin, Y is a linking group and X is a chelating group, optionally comprising a detectable radionuclide or a paramagnetic metal ion, and n is 1-3.
Claims15
A method for preparing a compound of the formula:
- wherein
- is cobalamin;
- is the carbonyl moiety derived by removal of an amino radical from a cobalamin amido group;
- X is cyano, hydroxy, methyl, or adenosyl, wherein adenosyl is:
- Y is a linking group;
- and
- Chel is a chelating group;
- the method comprising reacting a select carboxyl substituent of X— with a divalent bifunctional organic linking group;
- and
- reacting the linking group with a chelating group to provide the compound.
7 more elements
A method for preparing a compound of the formula:
- wherein
- is cobalamin;
- is the carbonyl moiety derived by removal of an amino radical from a cobalamin amido group;
- X is cyano, hydroxy, methyl, or adenosyl, wherein adenosyl is:
- Y is a linking group;
- and
- Chel is a chelating group;
- the method comprising reacting a select carboxyl substituent of X— with a divalent bifunctional organic linking group;
- reacting the linking group with a chelating group to provide the compound;
- and
- reacting the compound with a radionuclide or a paramagnetic metal ion to provide a compound of formula (I):
- wherein Det is a detectably labeled chelating group.
9 more elements
A method for preparing a compound of formula (I):
- wherein
- is cobalamin;
- is the carbonyl moiety derived by removal of an amino radical from a cobalamin amido group;
- X is cyano, hydroxy, methyl, or adenosyl, wherein adenosyl is
- Y is a linking group;
- and
- Det is a detectably labeled chelating group;
- the method comprising reacting a compound of the formula:
- wherein Chel is a chelating group, with a radionuclide or a paramagnetic metal ion, to provide the compound of formula (I).
6 more elements
Dependencies are inferred from the claim text.