Apoptosis polypeptide
AssigneeBoard of Regents, The University of Texas System
InventorsJohn M. Abrams, Po Chen, William Nordstrom
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Abstract
Disclosed is a Drosophila grim gene and encoded GRIM polypeptide, an activator of apoptosis. The disclosed nucleic acid sequences are useful in the production of the protein and as hybridization probes and primers. Expression of the GRIM protein causes programmed cell death. Preferred embodiments include expression of grim under the control of an inducible promoter and the use of such a construct in the control of an insect population.
Claims6
A purified polypeptide comprising the amino acid sequence set forth in SEQ ID NO:2, or a conservative substitution variant thereof.
An antigenic fragment of a polypeptide consisting of the sequence set forth in SEQ ID NO:2.
Dependencies are inferred from the claim text.