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US 6,211,243 B1Granted
Methods for treating cold sores with anti-infective compositions
OwnerB. Ron Johnsoninventor
Life of this patent
Estimating the term…
Abstract
The present invention relates to a method of treated disordered epithelial tissues such as cold sores and other complications resulting from disorders such as herpes, and the like. The inventive method combines an anti-infective and/or antimicrobial active agent in a carrier, with vigorous agitation of the disordered epithelial tissue for topical treatment thereof under such conditions sufficient to achieve clinically discernable improvement of the disordered epithelial tissue. The preferred anti-infective and/or antimicrobial active agent is an organohalide such as a quaternary ammonium compound, preferably benzalkonium chloride. The inventive method may be used also in connection with a preferred applicator configuration.
Claims51
A method of treating a cold sore comprising:
- identifying a cold sore treatment site;
- obtaining an applicator which holds a treatment composition for application to and penetration into the cold sore treatment site, wherein the treatment composition includes an anti-infective agent in a carrier, wherein the treatment composition is a liquid and has a viscosity that enhances rapid absorption into the cold sore treatment site without remaining on the cold sore treatment site for extended time periods;
- vigorously agitating the cold sore treatment site with the applicator in a manner such that the treatment composition is simultaneously delivered as the cold sore treatment site is agitated to enhance penetration of the treatment composition into the cold sore treatment site;
- and
- allowing the treatment composition to penetrate into the cold sore treatment site so that the composition is no longer visibly detectable on the cold sore treatment site within several minutes after delivery of the treatment composition onto the cold sore treatment site.
2 more elements
A method of treating a cold sore comprising:
- identifying a cold sore treatment site;
- obtaining an applicator which contains a treatment composition,
- wherein the applicator includes
- delivery and agitation means for delivering the treatment composition and for agitating the cold sore treatment site, and
- means for supporting the delivery means
- wherein the treatment composition includes an organohalide in a carrier, wherein the treatment composition is a liquid and has a viscosity that enhances rapid absorption into the cold sore treatment site without remaining on the cold sore treatment site for extended time periods;
- vigorously agitating the cold sore treatment site with the applicator in a manner such that the treatment composition is simultaneously delivered as the cold sore treatment site is agitated to enhance penetration of the treatment composition into the cold sore treatment site;
- and
- allowing the treatment composition to penetrate into the cold sore treatment site so that the composition is no longer visibly detectable on the cold sore treatment site within several minutes after delivery of the treatment composition onto the cold sore treatment site.
6 more elements
A method of treating a cold sore comprising:
- identifying a cold sore treatment site;
- obtaining an applicator which contains a treatment composition,
- wherein the applicator includes
- delivery and agitation means for delivering the treatment composition and for agitating the cold sore treatment site,
- means for supporting the delivery means, and
- reservoir means for containing the treatment composition;
- wherein the treatment composition includes an organohalide in a carrier, wherein the treatment composition is a liquid and has a viscosity that enhances rapid absorption into the cold sore treatment site without remaining on the cold sore treatment site for extended time periods;
- vigorously agitating the cold sore treatment site with the applicator in a manner such that the treatment composition is simultaneously delivered as the cold sore treatment site is agitated to enhance penetration of the treatment composition into the cold sore treatment site;
- and
- allowing the treatment composition to penetrate into the cold sore treatment site so that the composition is no longer visibly detectable on the cold sore treatment site within 2 minutes after delivery of the treatment composition onto the cold sore treatment site.
7 more elements
A method of treating a cold sore comprising:
- identifying a cold sore treatment site;
- obtaining an applicator which contains a treatment composition,
- wherein the applicator includes
- delivery and agitation means for delivering the treatment composition and for agitating the cold sore treatment site,
- means for supporting the delivery means, and
- reservoir means for containing the treatment composition and for providing fluid communication with the delivery and agitation means when use of the applicator is desired for application of the treatment composition;
- wherein the treatment composition includes an organohalide in a carrier, wherein the treatment composition is a liquid and has a viscosity that enhances rapid absorption into the cold sore treatment site without remaining on the cold sore treatment site for extended time periods;
- vigorously agitating the cold sore treatment site with the applicator in a manner such that the treatment composition is simultaneously delivered as the cold sore treatment site is agitated to enhance penetration of the treatment composition into the cold sore treatment site;
- and
- allowing the treatment composition to penetrate into the cold sore treatment site so that the composition is no longer visibly detectable on the cold sore treatment site within 2 minutes after delivery of the treatment composition onto the cold sore treatment site.
7 more elements
A method of treating a cold sore comprising:
- identifying a cold sore treatment site;
- obtaining an applicator which contains a treatment composition,
- wherein the applicator includes
- delivery and agitation means for delivering the treatment composition and for agitating the cold sore treatment site,
- means for supporting the delivery means, and
- reservoir means for containing the treatment composition and for providing continual fluid communication with the delivery and agitation means until all of the treatment composition held in the reservoir means has been delivered to the delivery and agitation means;
- wherein the treatment composition includes an organohalide in a carrier, wherein the treatment composition is a liquid and has a viscosity that enhances rapid absorption into the cold sore treatment site without remaining on the cold sore treatment site for extended time periods;
- rupturing the reservoir means to enable the treatment composition to be delivered to the delivery and agitation means;
- vigorously agitating the cold sore treatment site with the applicator in a manner such that the treatment composition is simultaneously delivered as the cold sore treatment site is agitated to enhance penetration of the treatment composition into the cold sore treatment site;
- and
- allowing the treatment composition to penetrate into the cold sore treatment site so that the composition is no longer visibly detectable on the cold sore treatment site within 2 minutes after delivery of the treatment composition onto the cold sore treatment site.
8 more elements
A method of treating a cold sore comprising:
- identifying a cold sore treatment site;
- obtaining an applicator which holds a treatment composition for application to and penetration into the cold sore treatment site, wherein the treatment composition includes an anti-infective agent in a carrier, wherein the treatment composition is a liquid and has a viscosity that enhances rapid absorption into the cold sore treatment site without remaining on the cold sore treatment site for extended time periods, wherein the treatment composition is substantially oil free;
- vigorously agitating the cold sore treatment site with the applicator in a manner such that the treatment composition is simultaneously delivered as the cold sore treatment site is agitated to enhance penetration of the treatment composition into the cold sore treatment site;
- and
- allowing the treatment composition to penetrate into the cold sore treatment site so that the composition is no longer visibly detectable on the cold sore treatment site within several minutes after delivery of the treatment composition onto the cold sore treatment site.
2 more elements
A method of treating a cold sore comprising:
- identifying a cold sore treatment site;
- obtaining an applicator which holds a treatment composition for application to and penetration into the cold sore treatment site, wherein the treatment composition includes an organohalide in a carrier, wherein the carrier includes isopropyl alcohol, wherein the treatment composition is a liquid and has a viscosity that enhances rapid absorption into the cold sore treatment site without remaining on the cold sore treatment site for extended time periods;
- vigorously agitating the cold sore treatment site with the applicator in a manner such that the treatment composition is simultaneously delivered as the cold sore treatment site is agitated to enhance penetration of the treatment composition into the cold sore treatment site;
- and
- allowing the treatment composition to penetrate into the cold sore treatment site so that the composition is no longer visibly detectable on the cold sore treatment site within several minutes after delivery of the treatment composition onto the cold sore treatment site.
2 more elements
A method of treating a cold sore comprising:
- identifying a cold sore treatment site;
- obtaining an applicator which holds a treatment composition for application to and penetration into the cold sore treatment site, wherein the treatment composition includes benzalkonium chloride in a carrier, wherein the treatment composition is a liquid and has a viscosity that enhances rapid absorption into the cold sore treatment site without remaining on the cold sore treatment site for extended time periods;
- vigorously agitating the cold sore treatment site with the applicator in a manner such that the treatment composition is simultaneously delivered as the cold sore treatment site is agitated to enhance penetration of the treatment composition into the cold sore treatment site;
- and
- allowing the treatment composition to penetrate into the cold sore treatment site so that the composition is no longer visibly detectable on the cold sore treatment site within several minutes after delivery of the treatment composition onto the cold sore treatment site.
2 more elements
A method of treating a cold sore comprising:
- identifying a cold sore treatment site;
- obtaining an applicator which holds a treatment composition for application to and penetration into the cold sore treatment site, wherein the treatment composition includes benzalkonium chloride in a carrier, wherein the carrier includes isopropyl alcohol, wherein the treatment composition is a liquid and has a viscosity that enhances rapid absorption into the cold sore treatment site without remaining on the cold sore treatment site for extended time periods;
- vigorously agitating the cold sore treatment site with the applicator in a manner such that the treatment composition is simultaneously delivered as the cold sore treatment site is agitated to enhance penetration of the treatment composition into the cold sore treatment site;
- and
- allowing the treatment composition to penetrate into the cold sore treatment site so that the composition is no longer visibly detectable on the cold sore treatment site within several minutes after delivery of the treatment composition onto the cold sore treatment site.
2 more elements
A method of treating a cold sore comprising:
- identifying a cold sore treatment site;
- obtaining an applicator which holds a treatment composition for application to and penetration into the cold sore treatment site, wherein the treatment composition includes benzalkonium chloride in a carrier, wherein the carrier includes isopropyl alcohol and water, wherein the treatment composition is a liquid and has a viscosity that enhances rapid absorption into the cold sore treatment site without remaining on the cold sore treatment site for extended time periods;
- vigorously agitating the cold sore treatment site with the applicator in a manner such that the treatment composition is simultaneously delivered as the cold sore treatment site is agitated to enhance penetration of the treatment composition into the cold sore treatment site;
- and
- allowing the treatment composition to penetrate into the cold sore treatment site so that the composition is no longer visibly detectable on the cold sore treatment-site within several minutes after delivery of the treatment composition onto the cold sore treatment site.
2 more elements
A method of treating a cold sore comprising:
- identifying a cold sore treatment site;
- obtaining an applicator which holds a treatment composition for application to and penetration into the cold sore treatment site, wherein the treatment composition includes benzalkonium chloride in a carrier, wherein the carrier is primarily isopropyl alcohol and includes water in an amount ranging from about 20% to about 40% by volume of the carrier;
- vigorously agitating the cold sore treatment site with the applicator in a manner such that the treatment composition is simultaneously delivered as the cold sore treatment site is agitated to enhance penetration of the treatment composition into the cold sore treatment site;
- and
- allowing the treatment composition to penetrate into the cold sore treatment site so that the composition is no longer visibly detectable on the cold sore treatment site within several minutes after delivery of the treatment composition onto the cold sore treatment site.
2 more elements
Dependencies are inferred from the claim text.