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US 6,211,225 B1Granted
Heterocyclic aminopyrrolidine derivatives as melatonergic agents
AssigneeBristol-Meyers Squibb Company
InventorsKatherine S. Takaki, Guanglin Luo, Stephen R. Bertenshaw
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Abstract
There is provided a novel series of heterocyclic aminopyrrolidine compounds of Formula I wherein R1, R2, R3, R4, W, Z and the wavy bond are as defined herein which bind to the human melatonin receptor and therefore are useful as melatonergic agents.
Claims12
A compound of the formula
- wherein
- the wavy bond represents the racemate, the (R)-enantiomer or the (S)-enantiomer;
- R1 and R2 each are independently hydrogen or halogen;
- W is CR5, CR5R6 or (CH2)n, with n=1-2;
- Z is CH2, CH or oxygen;
- R3 is hydrogen or C1-4 alkyl;
- R4 is C1-6 alkyl, C3-6 cycloalkyl, C1-3 haloalkyl, C2-6 alkenyl, C1-6 alkyamino, C3-6 cycloalkylamino, di(C1-4)alkylamino, C1-4 alkoxy (C1-4)alkyl, C1-4 alkylthio(C1-4)alkyl or C1-4 trifluoromethyl(C1-2)alkyl;
- and
- R5 and R6 each are independently hydrogen or C1-4 alkyl;
- or a nontoxic pharmaceutically acceptable salt, hydrate or solvate thereof.
7 more elements
Dependencies are inferred from the claim text.