Heterocyclic compounds, their production and use
AssigneeTakeda Chemical Industries, Ltd.
InventorsYu Momose, Etsuya Matsutani
Life of this patent
Estimating the term…
Abstract
Heterocyclic compounds represented by the general formula (I) wherein R stands for an optionally substituted aromatic heterocyclic group; X stands for oxygen atom, an optionally oxidated sulfur atom, —C(═O)— or —CH(OH)—; Y stands for CH or N; m denotes an integer of 0 to 10: n denotes an integer of 1 to 5: cyclic group stands for an optionally substituted aromatic azole group; and ring A is optionally further substituted, or salts thereof. The compound (I) possesses action of inhibiting tyrosine kinase and useful as antitumor agents.
Claims21
A heterocyclic compound represented by the formula:
- wherein R stands for an aromatic heterocyclic group which may be optionally substituted,
- X stands for an oxygen atom, an optionally oxidized sulfur atom, —C(═O)— or —CH(OH)—,
- Y stands for CH or N
- m stands for an integer of 1 to 10,
- n stands for an integer of 1 to 5,
- the cyclic group
- stands for an aromatic azole group which may be substituted, and the ring A may be further substituted,
- or a salt thereof.
A method for producing a compound represented by the formula:
- wherein R stands for an aromatic heterocyclic group which may be optionally substituted,
- X stands for oxygen atom, an optionally oxidized sulfur atom, —C(═O)— or —CH(OH),
- Y stands for CH or N,
- m stands for an integer of 1 to 10,
- n stands for an integer of 1 to 5,
- the cyclic group;
- stands for an aromatic azole group which may be substituted,
- and the ring A may be further substituted,
- or a salt thereof,
- which comprises reacting a compound represented by the formula:
- wherein W stands for a leaving group and other symbols are the same as above, or a salt thereof,
- with a compound represented by the formula:
- wherein the cyclic group;
- stands for an aromatic azole group which may be substituted, or a salt thereof.
Dependencies are inferred from the claim text.