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US 6,211,210 B1Granted
Diphenyl-1,2,3-thiadiazol-3-oxides, compositions and methods of use
AssigneeMerck Frosst Canada, Inc.
InventorsCheuk Kun Lau, Chun-Sing Li, Cameron Black, Michel Therien, Jacques Yves Gauthier
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Abstract
The invention encompasses compounds of Formula I as well as a method of treating COX-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula I. The invention also encompasses certain pharmaceutical compositions for treatment of COX-2 mediated diseases comprising compounds of Formula I.
Claims12
A compound of Formula I
- or a pharmaceutically acceptable salt thereof wherein:
- R 1 is selected from the group consisting of:
- (a) S(O)2CH3,
- (b) S(O)2NHR4,
- (c) S(O)2NHCOCF3,
- (d) S(O)(NH)CH3,
- (e) S(O)(NH)NH2,
- (f) S(O)(NH)NHCOCF3,
- (g) P(O)(CH3)OH, and
- (h) P(O)(CH3)NH2,
- R2 and R3 are each independently selected from the group consisting of:
- (a) hydrogen,
- (b) halo,
- (c) C1-6alkoxy,
- (d) C1-6alkylthio,
- (e) CN,
- (f) C1-3fluoroalkyl,
- (g) C1-6alkyl,
- (h) N3,
- (i) —CO2H,
- (j) —CO2—C1-4alkyl,
- (k) —C(R5)(R6)—OH,
- (l) —C(R5)(R6)—O—C1-4alkyl, and
- (m) —C1-6alkyl-CO2—R7;
- R4 is selected from the group consisting of H, C1-6alkyl, phenyl and benzyl;
- and
- R5, R6 and R7 are each independently selected from the group consisting of:
- (a) hydrogen, and
- (b) C1-6alkyl.
26 more elements
Dependencies are inferred from the claim text.