Muscarinic receptor agonists
AssigneeThe University of Toledo
InventorsWilliam S. Messer, Yang Cao, Walajapet G. Rajeswaran
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Abstract
A compound of Formula (I): wherein R is independently selected from (CH2)9−12, (CH2CH2)2O, (CH2CH2)3O2, (CH2CH2)4O3, (CH2CH2)5O4, (CH2CH2)6O5 or (CH2CH2CH2)3O2; or an acid addition salt or hydrate thereof. The compounds, with improved water solubility, have unusually high affinity for muscarinic receptors, and exhibit agonist activity useful in the treatment of neurological and other disorders, in which stimulating cholinergic activity is desirable.
Claims21
A compound of Formula (I):
- wherein R is independently selected from (CH2)9−12, CH2CH2OCH2CH2, CH2CH2OCH2CH2OCH2CH2, CH2CH2OCH2CH2OCH2CH2OCH2CH2, CH2CH2OCH2CH2OCH2CH2OCH2CH2OCH2CH2, CH2CH2OCH2CH2OCH2CH2OCH2CH2OCH2CH2OCH2CH2, CH2CH2CH2OCH2CH2CH2OCH2CH2CH2;
- or an acid addition salt or hydrate thereof.
A method for the treatment of neurological and other disorders, in which stimulating cholinergic activity is desirable, comprising administering an effective amount of a muscarinic receptor ligand exhibiting agonist activity comprising a compound of Formula (I):
- wherein R is independently selected from (CH2)9−12, [(CH2CH2)2O, (CH2CH2)3O2, (CH2CH2)4O3, (CH2CH2)5O4, (CH2CH2)6O5 or (CH2CH2CH2)3O2;] CH2CH2OCH2CH2, CH2CH2OCH2CH2OCH2CH2, CH2CH2OCH2CH2OCH2CH2OCH2CH2, CH2CH2OCH2CH2OCH2CH2OCH2CH2OCH2CH2, CH2CH2OCH2CH2OCH2CH2OCH2CH2OCH2CH2OCH2CH2, CH2CH2CH2OCH2CH2CH2OCH2CH2CH2;
- or an acid addition salt or hydrate thereof.
Dependencies are inferred from the claim text.