Multivalent salts of pyridostigmine and related compounds
AssigneeICN Pharmaceuticals, Inc.
InventorsColin Granger, Robert Orr, Kandasamy Ramasamy
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Abstract
A quaternary ammonium cholinergic agent is complexed with a multivalent anion, or with multiple monovalent anions. The complex may be administered orally to a patient to treat pain, or for some other purpose. Numerous modifications are contemplated, including modifications to the ring structure of the compound, substitution and functionalization of the ring. Other contemplated modifications include the use of different anions, including various monovalent and polyvalent anions, and both organic and inorganic anions. The compounds have utility as cholinergic agents, and especially in the treatment of mysasthenia gravis, chest pain, and carpal tunnel syndrome.
Claims20
A pharmaceutically effective cholinergic compound having a plurality of carbamate chemical groupings according to the formula, [Y—R—O—CO—NR1R2]+, the groupings covalently bound together in any of the following ways:
- (a) through the nitrogen atom alpha to the carbamate carbonyl;
- and
- (b) through a quaternary nitrogen atom in the ring structure of R;
- wherein R is a ring or ring system, Y is alkyl, substituted alkyl, aryl, substituted aryl, aralkyl, substituted aralkyl, or NR3R4R5 where R1, R2, R3, R3, R4 and R5 are independently H, alkyl, substituted alkyl, aryl, or substituted aryl;
- wherein all atoms external to and which covalently link two Rs have a neutral charge.
Dependencies are inferred from the claim text.